PAINT-IPDMA
An individual participant data meta-analysis (IPDMA) is a specific type of meta-analysis, for which the original data for each participant in a study are collected, checked, and re-analyzed in a systematic way. The IPDMA has also been described as the gold standard of systematic reviews because it can improve the completeness and quality of data and the breadth and flexibility of analysis.
We aim to gain more insight into psychosocial interventions for children and adolescents with ADHD and disruptive behaviors.
We are currently conducting systematic reviews to identify which studies are relevant to incorporate individual participant data into our IPDMA.
Read more about the latest IPDMA publication and results:
Goal of the project
Many well-designed studies have been performed to investigate the effectiveness of psychosocial interventions for ADHD and disruptive behavior. However, most studies did not have the opportunity to conduct well-powered moderator analysis. If all studies in this field are combined, we can look into factors influencing treatment efficacy and identify subgroups of families who respond better or worse to specific types of interventions. Hopefully this will lead to great advances in personalized care for children with ADHD and disruptive behaviors.
Why perform an IPDMA?
An IPDMA differs from aggregated data meta-analysis in that it uses the original participant data instead of results described in research articles. With this method it is possible to look whether a treatment is effective. Individual participant data has several advantages to aggregated data meta-analysis. First, statistical methods can be standardized across studies, reducing noise across studies. Second, moderators of treatment effects and effects in subgroups can be explored in a much more reliable way than in individual studies (because of the larger sample size) or aggregated data meta-analysis (because of the greater power compared to meta-regression). Third, with IPDMA missing data can be handled in the same way across trials. Importantly, IPDMA can contribute considerably to the development of personalized treatment for ADHD and disruptive behaviors.
What do we ask from the participants?
Once we identify all eligible studies, we will contact the corresponding authors to ask for their participation in the IPDMA. Principal investigators of eligible trials will be requested to send raw, anonymous data of all included participants, from all eligible conditions (i.e., intervention and control conditions) and all assessment points. Only the transfer of individual trial data is necessary for participation in the IPDMA.
Future plans
We plan to establish a large individual participant database that includes a worldwide range of parenting intervention studies (not yet covered in our current IPDMAs) on the broad group of referred children with externalizing behavior problems, including both children with and without an ADHD, ODD, or CD diagnosis. Specifically, we will include any type of intervention that focuses their efforts on parents as the main agents of change in child behavior. The aim is to gain more insight into the differential effectiveness of parenting interventions and identify optimal program content for individual children with externalizing problems.
Contact or Questionas?
If you have any questions please feel free to contact a.groenman@accare.nl or c.psyllou@accare.nl
Latest publications
Conference – Interventions for ADHD and Behavioural Problems
On 16 and 17 June 2022, the conference 'Interventions for ADHD and Behavioural Problems - What works for whom and why' took place. Under the fantastic leadership of Professor Saskia Van der Oord, the members [...]
Attachment in children with ADHD
In the general population, externalising behaviour seems to be associated with insecure attachment and lack of trust in caregiver support. Some studies in ADHD populations have shown that children with ADHD are more likely to [...]
Conference in honour of the inauguration of Barbara van den Hoofdakker
Better oars, more frequent rowing. On the treatment of behavioural problems in children'. This was the title of the inaugural lecture delivered by Prof. Barbara van den Hoofdakker on Friday 11 March 2022. Barbara van [...]
Other Projects
Paint-T
In the Paint-T trial, the effectiveness of the components of teacher training was examined by means of a microtrial, and in the follow-up study Paint T trial, the effectiveness of a combined teacher training will be examined.
PAINT-IPDMA
In PAINT-IPDMA, an individual participant data meta-analysis is being conducted on psychosocial treatments for children and adolescents with ADHD. In the follow-up IPDMA study, the psychosocial treatments for children and adolescents with behavioural problems are investigated.
PAINT-S
The aim of PAINT-S is to investigate the efficacy of an intervention to improve the interaction between children with ADHD and their siblings.
PAINT-C
The PAINT-C study maps the care for children with ADHD and/or hyperactive behaviour in the Netherlands at municipalities, CJGs/District Teams and schools and investigates what predicts treatment choices in ADHD.
PLOS
The study PLOS (Planning at School) investigates the effectiveness of a programme to support secondary school students with planning problems. PLOS consists of two parts PLOS-basic and PLOS-extra.
PAINT-P
In PAINT-P the effectiveness of the components of parental training for ADHD was studied and in the follow-up studies Paint-POH, Paint-GZ and Paint-Pc the effectiveness of combined parental training in different settings will be studied.