Why perform an IPDMA?
An An IPDMA differs from aggregated data meta-analysis in that it uses the original participant data instead of results described in research articles. This method makes it possible to examine if a treatment is effective. Individual participant data has several advantages to aggregated data meta-analysis:
1. Statistical methods can be standardized across studies, reducing noise
2. A larger sample size allows testing of moderators of treatment effects and effects in subgroups in a much more reliable way than in individual studies
3. Greater power to test moderators of treatment compared to meta-regression used in aggregated data meta-analysis
4. Allows handling of missing data in the same way across trials
With an IPDMA, we can contribute considerably to developing personalized interventions for ADHD and disruptive behaviors.